Acanthosis nigricans - 黑棘皮病
这种情况在肥胖者中很常见。
relevance score : -100.0%
ReferencesAcanthosis nigricans 是潜在疾病的皮肤表现。它常出现在颈部、腋窝和腹股沟等皮肤皱褶处，呈天鹅绒般的黑色斑块，边缘不清晰。该情况通常与糖尿病和胰岛素抵抗有关，但在极少数情况下，可能提示体内存在癌症。激素紊乱或使用类固醇、口服避孕药等特定药物也可导致其出现。
Acanthosis nigricans is a cutaneous manifestation of an underlying condition. It usually develops in skin folds, such as the back of the neck, axilla, and groin, where it presents as velvety hyper-pigmented patches with poorly defined borders. Acanthosis nigricans is most commonly associated with diabetes and insulin resistance, but rarely it can be a sign of internal malignancy. It can also occur with hormone disorders or with the use of certain medications like systemic glucocorticoids and oral contraceptives.
Acanthosis nigricans is a cutaneous manifestation of an underlying condition. It usually develops in skin folds, such as the back of the neck, axilla, and groin, where it presents as velvety hyper-pigmented patches with poorly defined borders. Acanthosis nigricans is most commonly associated with diabetes and insulin resistance, but rarely it can be a sign of internal malignancy. It can also occur with hormone disorders or with the use of certain medications like systemic glucocorticoids and oral contraceptives.
Acanthosis nigricans (AN) 是一种常见的皮肤病，常与胰岛素抵抗、糖尿病、肥胖、某些癌症、激素异常以及药物反应等健康问题相关。治疗 AN 的重点在于处理潜在的疾病。首先，医生会评估是否存在胰岛素抵抗综合征的表现，如肥胖、高胆固醇、高血压和 2 型糖尿病。常用的第一线治疗是局部使用 topical retinoids（维A酸类），它可以帮助改善皮肤增厚，但可能不足以完全消除色素沉着。其他可选的外用药物包括 salicylic acid（水杨酸）、podophyllin（白头翁酚）、urea（尿素）和 calcipotriol（卡泊三醇），需要根据患者情况长期使用。
Acanthosis nigricans (AN) is a common dermatologic manifestation of systemic disease that is associated with insulin resistance, diabetes mellitus, obesity, internal malignancy, endocrine disorders, and drug reactions. Treatment of AN primarily focuses on resolution of the underlying disease processes causing the velvety, hyperpigmented, hyperkeratotic plaques found on the skin. Initial considerations for the AN workup include evaluating patients for insulin resistance syndrome characterized by obesity, dyslipidemia, hypertension, and diabetes mellitus type II. For cosmetic treatment, topical retinoids are considered the first-line therapy for insulin-resistant AN by modifying keratinization rate. However, topical tretinoin requires application for long durations and improves hyperkeratosis, but not hyperpigmentation. Topical salicylic acid, podophyllin, urea, and calcipotriol also require frequent application, while TCA peels may provide a faster and less time-intense burden.
Acanthosis nigricans (AN) is a common dermatologic manifestation of systemic disease that is associated with insulin resistance, diabetes mellitus, obesity, internal malignancy, endocrine disorders, and drug reactions. Treatment of AN primarily focuses on resolution of the underlying disease processes causing the velvety, hyperpigmented, hyperkeratotic plaques found on the skin. Initial considerations for the AN workup include evaluating patients for insulin resistance syndrome characterized by obesity, dyslipidemia, hypertension, and diabetes mellitus type II. For cosmetic treatment, topical retinoids are considered the first-line therapy for insulin-resistant AN by modifying keratinization rate. However, topical tretinoin requires application for long durations and improves hyperkeratosis, but not hyperpigmentation. Topical salicylic acid, podophyllin, urea, and calcipotriol also require frequent application, while TCA peels may provide a faster and less time-intense burden.
○ 原因
多见于40岁以下个体，可能具有遗传倾向，并与肥胖或内分泌疾病相关，如甲状腺功能减退、肢端肥大症、多囊卵巢综合征、胰岛素抵抗性糖尿病或库欣综合征。
○ 治疗 - 非处方药
#40% urea cream